Enrolling | Clinical Trial | Single-Decentralized Trial | Zevra Therapeutics A Phase 3 Randomized, Double-Blind, Decentralized Clinical Trial To Compare The Efficacy Of Celiprolol To Placebo In The Treatment Of Patients With Col3a1-Positive Vascular Ehlers-Danlos...
Arterial Ischemic Stroke
Tolerability of transcranial direct current stimulation in Pediatric Stroke Survivors 2
Enrolling | Clinical Trial | Single Site | UTHeath Houston McGovern Medical School The TOPSS 2 study (Tolerability of transcranial direct current stimulation in Pediatric Stroke Survivors 2) is recruiting children and teens aged 5–19 years who have arm weakness...
Australian Paediatric Acute Code Stroke (PACS) Study
Enrolling | Intervention | Multicenter | Murdoch Children's Research Institute & The Stroke Foundation The Stroke Foundation is partnering with Murdoch Children’s Research Institute and researchers, health professionals, industry and patients to transform the care of...
Interview with Dr. Peter Sporns, author of the Save ChildS Study
By Nidhi Ravishankar & Arpita Lakhotia.The Save ChildS study1 is the first retrospective, multicenter cohort study that analyzed databases from 27 stroke centers in the United States and Europe suggesting comparable safety data for endovascular thrombectomy (EVT)...
Deficiency of adenosine deaminase 2 (ADA2), what are we missing?
By Ariane Soldatos & Amanda Ombrello. Case: A previously healthy 14-year-old patient presents with a small stroke in the basal ganglia following upper respiratory symptoms. You do the usual vascular, cardiac and thrombophilia work-up which is unrevealing. You...
Reflections on the first IPSO Virtual Conference
By Grégoire Boulouis, Peter Sporns and Jenny Wilson. IPSO had its first conference July 19-21, 2021 after COVID-19 obliterated plans for an in-person conference in 2020 in Vienna, Austria. While there was a feeling of disappointment in not being able to meet in...
Predictive Value of Imaging Features in Pediatric Acute Ischemic Stroke
By Bin Jiang and Warren Lo. The rehabilitation center at Stanford Children’s Health is home to pediatric patients who have suffered a pediatric arterial ischemic stroke (AIS). Their prolonged rehabilitation process and their determined mindset has left deep...
Dysphagia, Motor Speech and Language Following Pediatric Ischemic Stroke
By Victoria Sherman and Mahendra Moharir. It was during my clinical work as a Speech-Language Pathologist (SLP) at an adult acute care hospital in Toronto where I initially realized the true prevalence of dysphagia following adult stroke and its impact on patient...
COVID-19 and Pediatric Stroke: What is the Connection?
By Lauren A. Beslow.In May 2020, the New England Journal of Medicine reported a series of 5 young adult patients who presented to the same hospital in a two-week period with larger artery strokes as a presenting feature of COVID-19. This high profile NEJM...
The International Paediatric Stroke Study (IPSS): A highly successful study vehicle for paediatric stroke research on a global scale
By Nomazulu Dlamini and Alexandra Linds. The International Paediatric Stroke Study (IPSS) was established in 2003 through a visionary collaboration of 11 international colleagues with expertise in paediatric stroke. For over 15 years, the IPSS has served as the...
Teamwork in Pediatric Stroke
By Jenny Wilson and Peter Sporns. Many pediatric hospitals have developed systems to respond to an acute pediatric stroke. These systems involve collaboration between physicians, nurses, and other experts hospital-wide from a diverse set of backgrounds and training,...
Return to school during the COVID pandemic: Information for families with children affected by stroke
By Adam Kirton.As clinicians caring for children with stroke and cerebrovascular disease, most of us have been fielding questions from parents about whether they need to take special precautions to protect their children during the pandemic. There are no clear...
Pediatric Stroke Awareness and Code Stroke Protocols
By Lori Jordan.May is pediatric stroke awareness month. Recognizing a stroke in a child can be difficult. I have been reflecting on how important it is for all healthcare providers and families in our communities to know that strokes occur in children. We recently...
COVID-19 and pediatric stroke—is there a connection?
By Heather Fullerton.One of our earliest pediatric mechanical thrombectomy cases at UCSF Benioff Children’s Hospital was during the 2003 SARS global outbreak. Some of you may remember how children suffered more severe respiratory illnesses with that other...
Vascular effects of Infection in Pediatric Stroke II (VIPS)
| Enrolling | Observational | Multi-site | NIH | Heather Fullerton | VIPS II is an international multi-center NIH funded study that proposes to enroll 200 pediatric stroke cases and 200 pediatric stroke-free cases. Biological specimens, imaging, parent interviews and...
Feasibility, Safety and Outcome of Endovascular Recanalization in Childhood Stroke: a worldwide multicenter prospective registry (Save ChildS Pro)
| Enrolling | Prospective Observational Registry |Multi-Site | Peter Sporns | Save ChildS Pro is a prospective registry including all pediatric patients with large vessel occlusion arterial ischemic stroke either treated with endovascular thrombectomy or best medical...
Seizures in Pediatric Stroke II (SIPS)
| Closed | Observational | Multi-site | PERF | Christine Fox| SIPS II is an international multi-center PERF funded study that proposed to enroll 300 neonatal and pediatric stroke cases. Imaging, EEGs, medical chart abstraction and epilepsy longitudinal outcome data...
Rehabilitation Early for Congenital Hemiplegia
|Enrolling |Clinical Trial | Multi-Site |Professor Roslyn Boyd | The REACH multisite assessor masked randomized Comparison trial directly compares an equal dose of infant modified Constraint Induced Movement Therapy (Baby CIMT) with infant modified Bimanual upper limb...
Parental Emotional Outcomes in Perinatal Stroke (POPS)
| Enrolling | Observational | Multi-site | Boston Children’s Hospital | Laura Lehman | The POPS study is a prospective multi-site IPSS sub-study that investigates whether an educational video on perinatal stroke etiology will decrease the emotional burden of guilt and...
Examination of PTSD, Anxiety, Depression in parents and children with pediatric arterial ischemic stroke (AIS) and association with stroke outcome (PIPS)
| Enrolling | Observational | Multi-site | Boston Children’s Hospital | Laura Lehman| The PIPS study is a prospective multi-site IPSS sub-study that investigates the association between emotional outcomes (PTSD, anxiety, and depression) and AIS. The study uses...
Advanced Neuroimaging in Pediatric Stroke: Pathophysiology of Injury and Repair in Children with Focal Brain Ischemia
| Enrolling | Observational | Multi-site | Brain Canada | Noma Dlamini | The Brain Canada study is the first multi-center, international, advanced prospective neuroimaging study in childhood stroke. The study focuses on using novel neuroimaging techniques to...
Risk Factors Associated With Stroke in Pediatric Patients Undergoing Fontan
Rehabilitation Early for Congenital Hemiplegia
|Enrolling |Clinical Trial | Multi-Site |Professor Roslyn Boyd | The REACH multisite assessor masked randomized Comparison trial directly compares an equal dose of infant modified Constraint Induced Movement Therapy (Baby CIMT) with infant modified Bimanual upper limb...