Enrolling | Intervention | Multicenter | Murdoch Children's Research Institute & The Stroke Foundation The Stroke Foundation is partnering with Murdoch Children’s Research Institute and researchers, health professionals, industry and patients to transform the care of...
Research Studies
COL4A1/2 Natural History Registry
Research Study Type (Registry, Observational, Clinical Trial, Other): Registry/Observational Research Status (In Development, Enrolling, Analysis): Enrolling Site Type (Single Site, Multi-Site): Single Site Variants in COL4A1/2 are increasingly recognized as a cause...
EPIC-LVO
Research Study Type (Registry, Observational, Clinical Trial, Other): Prospective pilot study Research Status (In Development, Enrolling, Analysis): Enrolling Site Type (Single Site, Multi-Site): Multi-site EPIC-LVO is a prospective pilot study assessing the...
Research Studies on Recovery of Language and Cognitive Skills after Pediatric Stroke Washington, DC, area
In our ongoing work, researchers at the Center for Brain Plasticity and Recovery (CBPR) at Georgetown University Medical Center in Washington, DC, are studying the effects of childhood stroke on cognitive and language abilities. Drs. Elissa Newport, William Gaillard,...
Vein of Galen Malformation Genetics Research Consortium (VOGM-GRC)
| Enrolling | Observational | Multi-Center Site | Andrew T. Hale & Jesse Jones | Vein of Galen malformations (VOGMs) are the most common and severe neonatal blood vessel anomaly of the human cerebral vasculature. VOGM are the result of abnormal connections between...
The International Paediatric Stroke Study (IPSS): A highly successful study vehicle for paediatric stroke research on a global scale
By Nomazulu Dlamini and Alexandra Linds. The International Paediatric Stroke Study (IPSS) was established in 2003 through a visionary collaboration of 11 international colleagues with expertise in paediatric stroke. For over 15 years, the IPSS has served as the...
Investigating Outcome Prediction and Rehabilitation from childhood stroke via the use of EEG brain connectivity assessments
| In Development | Observational | Single Site | Kartik Iyer, Michaela Waak & Karen Barlow | Predicting clinical recovery in childhood stroke is highly challenging due to the complex nature of injury. Outcomes in these children remain unclear until months after...
Pediatric Intracerebral Hemorrhage (PICH)
| Analysis | Observational |Single Site | Grégoire Boulouis, Thomas Blauwblomme, Manoelle Kossorotoff and Olivier Naggara | The PICH study aims at delineating candidate biomarkers to develop targeted therapeutic strategies to improve outcome of children with...
Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation (I-ACQUIRE)
| Enrolling | Clinical Trial | Multi-site | StrokeNet NIH | Sharon L. Ramey & Warren Lo | This is a Phase III clinical trial to compare the efficacy of two dosages of a new infant rehabilitation protocol - I-ACQUIRE - to usual and customary forms of infant...
Vascular effects of Infection in Pediatric Stroke II (VIPS)
| Enrolling | Observational | Multi-site | NIH | Heather Fullerton | VIPS II is an international multi-center NIH funded study that proposes to enroll 200 pediatric stroke cases and 200 pediatric stroke-free cases. Biological specimens, imaging, parent interviews and...
PASTA (Paediatric Arteriopathy Steroid Aspirin: high dose steroids in children with stroke and unilateral focal arteriopathy) trial. EudraCT 2017-002247-15
|In Development |Clinical Trial |Multi-Site study | Maja Steinlin, Stéphane Chabrier & Manoëlle Kossorotoff | The main goal of PASTA is to determine if a short high dose course of Methylprednisolone/Prednisolone (three intravenous pulses followed by a 4-week oral...
Feasibility, Safety and Outcome of Endovascular Recanalization in Childhood Stroke: a worldwide multicenter prospective registry (Save ChildS Pro)
| Enrolling | Prospective Observational Registry |Multi-Site | Peter Sporns | Save ChildS Pro is a prospective registry including all pediatric patients with large vessel occlusion arterial ischemic stroke either treated with endovascular thrombectomy or best medical...
Seizures in Pediatric Stroke II (SIPS)
| Closed | Observational | Multi-site | PERF | Christine Fox| SIPS II is an international multi-center PERF funded study that proposed to enroll 300 neonatal and pediatric stroke cases. Imaging, EEGs, medical chart abstraction and epilepsy longitudinal outcome data...
Rehabilitation Early for Congenital Hemiplegia
|Enrolling |Clinical Trial | Multi-Site |Professor Roslyn Boyd | The REACH multisite assessor masked randomized Comparison trial directly compares an equal dose of infant modified Constraint Induced Movement Therapy (Baby CIMT) with infant modified Bimanual upper limb...
Parental Emotional Outcomes in Perinatal Stroke (POPS)
| Enrolling | Observational | Multi-site | Boston Children’s Hospital | Laura Lehman | The POPS study is a prospective multi-site IPSS sub-study that investigates whether an educational video on perinatal stroke etiology will decrease the emotional burden of guilt and...
Examination of PTSD, Anxiety, Depression in parents and children with pediatric arterial ischemic stroke (AIS) and association with stroke outcome (PIPS)
| Enrolling | Observational | Multi-site | Boston Children’s Hospital | Laura Lehman| The PIPS study is a prospective multi-site IPSS sub-study that investigates the association between emotional outcomes (PTSD, anxiety, and depression) and AIS. The study uses...
Advanced Neuroimaging in Pediatric Stroke: Pathophysiology of Injury and Repair in Children with Focal Brain Ischemia
| Enrolling | Observational | Multi-site | Brain Canada | Noma Dlamini | The Brain Canada study is the first multi-center, international, advanced prospective neuroimaging study in childhood stroke. The study focuses on using novel neuroimaging techniques to...
Safety and Efficacy of Systemic Anticoagulation Therapy for Treatment of Cerebral Sinus Venous
Risk Factors Associated With Stroke in Pediatric Patients Undergoing Fontan
Rehabilitation Early for Congenital Hemiplegia
|Enrolling |Clinical Trial | Multi-Site |Professor Roslyn Boyd | The REACH multisite assessor masked randomized Comparison trial directly compares an equal dose of infant modified Constraint Induced Movement Therapy (Baby CIMT) with infant modified Bimanual upper limb...
AVCnn (Accident vasculaire cérébral du nouveau-né; Stroke of the newborn) & ancillary AVCnnsignal (brain structural and functional imaging) and AVCnn7ans (global assessment at 7 years). NCT02511249; EudraCT 2010-A00329-30; EndraCT 2010-A00976-33
| Enrolling | Observational |Single Site | Stéphane Chabrier & Sylvie Nguyen The Tich| The AVCnn Study provides us the opportunity to monitor a cohort of children having suffered an NAIS, and their family. Briefly, 100 term newborns (64 males) with an arterial...