By Adam Kirton. There is a general assumption that the developing brain is more plastic. While supported by scientific evidence dating back nearly 100 years, the mechanisms remain poorly understood. It is certainly true that children with strokes are different in many...
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Pediatric Stroke Awareness and Code Stroke Protocols
By Lori Jordan.May is pediatric stroke awareness month. Recognizing a stroke in a child can be difficult. I have been reflecting on how important it is for all healthcare providers and families in our communities to know that strokes occur in children. We recently...
COVID-19 and pediatric stroke—is there a connection?
By Heather Fullerton.One of our earliest pediatric mechanical thrombectomy cases at UCSF Benioff Children’s Hospital was during the 2003 SARS global outbreak. Some of you may remember how children suffered more severe respiratory illnesses with that other...
Investigating Outcome Prediction and Rehabilitation from childhood stroke via the use of EEG brain connectivity assessments
| In Development | Observational | Single Site | Kartik Iyer, Michaela Waak & Karen Barlow | Predicting clinical recovery in childhood stroke is highly challenging due to the complex nature of injury. Outcomes in these children remain unclear until months after...
Pediatric Intracerebral Hemorrhage (PICH)
| Analysis | Observational |Single Site | Grégoire Boulouis, Thomas Blauwblomme, Manoelle Kossorotoff and Olivier Naggara | The PICH study aims at delineating candidate biomarkers to develop targeted therapeutic strategies to improve outcome of children with...
Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation (I-ACQUIRE)
| Enrolling | Clinical Trial | Multi-site | StrokeNet NIH | Sharon L. Ramey & Warren Lo | This is a Phase III clinical trial to compare the efficacy of two dosages of a new infant rehabilitation protocol - I-ACQUIRE - to usual and customary forms of infant...
Vascular effects of Infection in Pediatric Stroke II (VIPS)
| Enrolling | Observational | Multi-site | NIH | Heather Fullerton | VIPS II is an international multi-center NIH funded study that proposes to enroll 200 pediatric stroke cases and 200 pediatric stroke-free cases. Biological specimens, imaging, parent interviews and...
PASTA (Paediatric Arteriopathy Steroid Aspirin: high dose steroids in children with stroke and unilateral focal arteriopathy) trial. EudraCT 2017-002247-15
|In Development |Clinical Trial |Multi-Site study | Maja Steinlin, Stéphane Chabrier & Manoëlle Kossorotoff | The main goal of PASTA is to determine if a short high dose course of Methylprednisolone/Prednisolone (three intravenous pulses followed by a 4-week oral...
Feasibility, Safety and Outcome of Endovascular Recanalization in Childhood Stroke: a worldwide multicenter prospective registry (Save ChildS Pro)
| Enrolling | Prospective Observational Registry |Multi-Site | Peter Sporns | Save ChildS Pro is a prospective registry including all pediatric patients with large vessel occlusion arterial ischemic stroke either treated with endovascular thrombectomy or best medical...
Seizures in Pediatric Stroke II (SIPS)
| Closed | Observational | Multi-site | PERF | Christine Fox| SIPS II is an international multi-center PERF funded study that proposed to enroll 300 neonatal and pediatric stroke cases. Imaging, EEGs, medical chart abstraction and epilepsy longitudinal outcome data...
Rehabilitation Early for Congenital Hemiplegia
|Enrolling |Clinical Trial | Multi-Site |Professor Roslyn Boyd | The REACH multisite assessor masked randomized Comparison trial directly compares an equal dose of infant modified Constraint Induced Movement Therapy (Baby CIMT) with infant modified Bimanual upper limb...
Parental Emotional Outcomes in Perinatal Stroke (POPS)
| Enrolling | Observational | Multi-site | Boston Children’s Hospital | Laura Lehman | The POPS study is a prospective multi-site IPSS sub-study that investigates whether an educational video on perinatal stroke etiology will decrease the emotional burden of guilt and...
Examination of PTSD, Anxiety, Depression in parents and children with pediatric arterial ischemic stroke (AIS) and association with stroke outcome (PIPS)
| Enrolling | Observational | Multi-site | Boston Children’s Hospital | Laura Lehman| The PIPS study is a prospective multi-site IPSS sub-study that investigates the association between emotional outcomes (PTSD, anxiety, and depression) and AIS. The study uses...
Advanced Neuroimaging in Pediatric Stroke: Pathophysiology of Injury and Repair in Children with Focal Brain Ischemia
| Enrolling | Observational | Multi-site | Brain Canada | Noma Dlamini | The Brain Canada study is the first multi-center, international, advanced prospective neuroimaging study in childhood stroke. The study focuses on using novel neuroimaging techniques to...
Safety and Efficacy of Systemic Anticoagulation Therapy for Treatment of Cerebral Sinus Venous
Risk Factors Associated With Stroke in Pediatric Patients Undergoing Fontan
Rehabilitation Early for Congenital Hemiplegia
|Enrolling |Clinical Trial | Multi-Site |Professor Roslyn Boyd | The REACH multisite assessor masked randomized Comparison trial directly compares an equal dose of infant modified Constraint Induced Movement Therapy (Baby CIMT) with infant modified Bimanual upper limb...
AVCnn (Accident vasculaire cérébral du nouveau-né; Stroke of the newborn) & ancillary AVCnnsignal (brain structural and functional imaging) and AVCnn7ans (global assessment at 7 years). NCT02511249; EudraCT 2010-A00329-30; EndraCT 2010-A00976-33
| Enrolling | Observational |Single Site | Stéphane Chabrier & Sylvie Nguyen The Tich| The AVCnn Study provides us the opportunity to monitor a cohort of children having suffered an NAIS, and their family. Briefly, 100 term newborns (64 males) with an arterial...